In 1989, Vega produced the instrumental "Don't Tell Me" for SBK Records and "Keep Pumpin' It Up" under the name Freestyle Orchestra. Vega had been commissioned to do songs for the movie East Side Story when he met the singer Marc Anthony. With Anthony, Vega would sign on to CBS Records' subsidiary WTG Records. Together they produced the single "Ride on the Rhythm," which did remarkably well in the clubs and rewarded both men with lots of recognition. He would later team up with house vocalist Barbara Tucker to produce Beautiful People and also establish the Underground Network Club in New York. Vega also teamed up again with Todd Terry to produce "Todd's Message" with vocalist La India, Vega's former wife. Vega also contributed to the Dee-Lite remix compilation Sampladelic Relics and Dance Floor Oddities.
Though Vega has produced much as a solo act, he is more widely known as half of the production team Masters at Work. Kenny "Dope" Gonzalez, who originally used the name for his own DJ crew, met Vega through Todd Terry. Under the Masters at Work name, Vega and Gonzalez have remixed the likes of Jamiroquai, Madonna, and Michael Jackson. Using the name Nuyorican Soul, the two worked with such jazz legends as Tito Puente and George Benson for a self-titled album. The two stopped all MAW remixes to concentrate on the 1997 album that strongly reflects their Puerto Rican heritage and returns the two to their roots as producers. In 2000, Vega appeared on the Ultra Records compilation House Nation America with Eric Morillo. ~ Diane Potts, All Music Guide